NARINGIN'S POTENTIAL AS A HEPATITIS B VIRUS REPLICATION INHIBITOR: AN IN-SILICO STUDY OF SECONDARY METABOLITE COMPOUND

Naringin is a secondary metabolite compound of the flavonoid group which generally found in plants that are consumed and traditionally used as medicine. The aim this study was to examine potential naringin candidate for hepatitis B virus replication inhibitor using an in-silico approach. This research uses exploratory descriptive method with molecular docking analysis carried out blind technique. 3D structures reference ligands were collected from PubChem database, target proteins PDB database. protein capsid ID: 5GMZ. Docking performed AutoDock Vina integrated into PyRx. results visualized PyMol software Biovia Discovery Studio 2019. showed binding affinity all simulation models between HBV ranged -7.1 -7.9 kcal/mol. site formed receptor corresponds ligand, involving same 12 amino acid residues, namely PHE 23, PRO 25, LEU 30, THR 33, TRP 102, ILE 105, SER 106, 110, TYR 118, 139, 140, 141. Based on these results, it can be concluded has bioactivity ligand inhibiting viral replication, so